Bone Scintigraphy and Hybrid Imaging in Pediatric Musculoskeletal Cases
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P: 69-81
March 2022

Bone Scintigraphy and Hybrid Imaging in Pediatric Musculoskeletal Cases

Nucl Med Semin 2022;8(1):69-81
1. Ankara Şehir Hastanesi, Nükleer Tıp Eğitim Kliniği, Ankara, Türkiye
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Publish Date: 15.04.2022
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ABSTRACT

Bone scintigraphy performed for pathologies concerning the skeletal system in pediatric patients is mostly used in the screening of benign pathologies. Although it seems to have lost some of its importance compared to previous years due to the widespread use of molecular imaging and the increase in the number of radiopharmaceuticals used, because of low radiation exposure and high sensitivity, it is still preferred in the childhood period. In cases where conditions such as septic arthritis, osteomyelitis or child abuse cannot be detected by clinical examination, the ability to scan the whole body with high sensitivity and especially when it is necessary to detect early bone reaction and start treatment early provides superiority over conventional radiological examinations. Bone scintigraphy, which is mostly used for malignancy screening in the adult age group, is also used to identify malignant and benign bone lesions specific to the childhood age group, to evaluate the multiple involvement of the disease and to determine the treatment response.

References

1Schmit P, Glorion C. Osteomyelitis in infants and children. European Radiology Supplements 2004;14:1-1.
2Alshammari A, Ashkanani R, Elgazzar A, Usmani S. Chronic Recurrent Multifocal Osteomyelitis in Children: A Multidisciplinary Approach is needed to establish a Diagnosis. World J Nucl Med 2013;12:120.
3Acikgoz G, Averill LW. Chronic recurrent multifocal osteomyelitis: typical patterns of bone involvement in whole-body bone scintigraphy. Nuclear Medicine Communications 2014;35:797-807.
4Açoğlu EA, Akçaboy M, Yıldız YT, et al. Kronik rekürren multifokal osteomyelit: olgu sunumu. 2019.
5Drubach LA, Sapp MarkV, Laffin S, Kleinman PK. Fluorine-18 NaF PET imaging of child abuse. Pediatr Radiol 2008;38:776-779.
6Drubach LA, Connolly SA, Palmer EL. Skeletal Scintigraphy With 18F-NaF PET for the Evaluation of Bone Pain in Children. AJR Am J Roentgenol 2011;197:713-719.
7Usmani S, Van den Wyngaert T, Ahmed N, et al. Technical feasibility, radiation dosimetry and clinical use of 18F-sodium fluoride (NaF) in evaluation of metastatic bone disease in pediatric population. Ann Nucl Med 2018;32:594-601.
8Blangis F, Taylor M, Adamsbaum C, et al. Add-on bone scintigraphy after negative radiological skeletal survey for the diagnosis of skeletal injury in children suspected of physical abuse: a systematic review and meta-analysis. Arch Dis Child 2021;106:361-366.
9Kleinman PK, Marks SC. A regional approach to classic metaphyseal lesions in abused infants: the distal tibia. AJR Am J Roentgenol 1996;166:1207-1212.
10Mandelstam SA, Cook D, Fitzgerald M, Ditchfield MR. Complementary use of radiological skeletal survey and bone scintigraphy in detection of bony injuries in suspected child abuse. Arch Dis Child 2003;88:387-390; discussion 387-390.
11Zwas ST, Elkanovitch R, Frank G. Interpretation and classification of bone scintigraphic findings in stress fractures. J Nucl Med 1987;28:452-457.
12Villani MF, Falappa P, Pizzoferro M, et al. Role of three-phase bone scintigraphy in paediatric osteoid osteoma eligible for radiofrequency ablation. Nucl Med Commun 2013;34:638-644.
13Ferrell J, Sharp S, Kumar A, Jordan M, Picarsic J, Nelson A. Discrepancies between F-18-FDG PET/CT findings and conventional imaging in Langerhans cell histiocytosis. Pediatr Blood Cancer 2021;68.
14Kesim S, Turoğlu HT, İnanır S, Özgüven S, Erdil TY. The Role of a Bone SPECT/CT Scan in the Follow-up of a Solitary Bone Lesion in a Patient with Langerhans’ Cell Histiocytosis. Mol Imaging Radionucl Ther 2021;30:187-189.
15Mueller WP, Melzer HI, Schmid I, Coppenrath E, Bartenstein P, Pfluger T. The diagnostic value of 18F-FDG PET and MRI in paediatric histiocytosis. Eur J Nucl Med Mol Imaging 2013;40:356-363.
16Drubach LA. Nuclear Medicine Techniques in Pediatric Bone Imaging. Semin Nucl Med 2017;47:190-203.
17Costelloe CM, Chuang HH, Daw NC. PET/CT of Osteosarcoma and Ewing Sarcoma. Semin Roentgenol 2017;52:255-268.
18Hack RI, Becker AS, Bode-Lesniewska B, et al. When SUV Matters: FDG PET/CT at Baseline Correlates with Survival in Soft Tissue and Ewing Sarcoma. Life (Basel) 2021;11:869.
19Albano D, Dondi F, Schumacher RF, et al. Clinical and Prognostic Role of 18F-FDG PET/CT in Pediatric Ewing Sarcoma. J Pediatr Hematol Oncol 2020;42:e79-e86.
20Whelan JS, Davis LE. Osteosarcoma, Chondrosarcoma, and Chordoma. J Clin Oncol 2018;36:188-193.
21Drubach LA, Johnston PR, Newton AW, Perez-Rossello JM, Grant FD, Kleinman PK. Skeletal Trauma in Child Abuse: Detection with 18 F-NaF PET. Radiology 2010;255:173-181.
22Sharma P, Singh H, Bal C, Kumar R. Non-ossifying fibroma mimicking distant metastasis of osteosarcoma on (99m)Tc-methylene diphosphonate bone scintigraphy: Diagnosis with single photon emission tomography/computed tomography. Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India. 2014;29.
23Hung W-L, Chan H-Y, Kuo N-C, Chan H-P. Monostotic Fibrous Dysplasia Mimicking Metastasis in the Femoral Neck on Bone Scintigraphy and 18F-FDG PET/CT. Diagnostics (Basel) 2020;10:E682.
24Lapietra G, Moleti ML, Giona F, et al. Polyostotic Fibrous Dysplasia Mimicking Bone Involvement in Hodgkin Lymphoma: A Pediatric Case and Literature Review. Acta Haematol 2021;144:212-217.
25Lee T-H, Chu L-S, Chang C-Y, Huang W-S. Different Pattern of Bone Scintigraphy in Mandibular Osteosarcoma Arising From Fibrous Dysplasia in a Patient With McCune-Albright Syndrome. Clin Nucl Med 2021;46:e11-e12.
26Choi YJ, Hwang HS, Kim HJ, et al. 18F-FDG PET as a single imaging modality in pediatric neuroblastoma: comparison with abdomen CT and bone scintigraphy. Ann Nucl Med 2014;28:304-313.
27Podrasky A, Stark D, Hattner R, Gooding C, Moss A. Radionuclide bone scanning in neuroblastoma: skeletal metastases and primary tumor localization of 99mTc-MDP. AJR Am J Roentgenol 1983;141:469-472.
28Tripathi M, Arora S, Dhull V, Mukherjee A, Tulsyan S, Behera A. Metastatic superscan on 99m Tc-methylene diphosphonate bone scintigraphy in pediatric neuroblastoma. Indian J Nucl Med 2015;30:286.
29Miller SF. Imaging features of juxtacortical chondroma in children. Pediatr Radiol 2014;44:56-63.
30Young CL, Sim FH, Unni KK, McLeod RA. Chondrosarcoma of bone in children. Cancer 1990;66:1641-1648.
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