Radionuclide Cardiac Imaging in Infective Endocarditis
PDF
Cite
Share
Request
Review
VOLUME: 10 ISSUE: 1
P: 28 - 41
April 2024

Radionuclide Cardiac Imaging in Infective Endocarditis

Nucl Med Semin 2024;10(1):28-41
1. Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, Ankara, Türkiye
2. Ankara Bilkent Şehir Hastanesi, Nükleer Tıp Kliniği, Ankara, Türkiye
3. Ondokuz Mayıs Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, Samsun, Türkiye
No information available.
No information available
Publish Date: 05.04.2024
PDF
Cite
Share
Request

ABSTRACT

Infective endocarditis (IE) is a microbial infection that can develop on the endocardial surface, native or prosthetic heart valves and implantable cardiac devices. The role of radionuclide imaging modalities in the management of IE has become prominent with the recently updated suggestions in the European Society of Cardiology guideline and Duke- International Society of Cardiovascular Infectious Diseases (Duke-ISCVID) diagnostic criteria. In this review, the basic principles of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography and labeled leukocyte scintigraphy, which are the main radionuclide imaging methods for the diagnosis of IE are examined along with their role in clinical practice and potential future applications are discussed in light of updated guidelines.

Keywords:
Invective endocarditis, F-18 FDG PET/CT, labelled leukocyte scintigraphy

References

1
Delgado V, Ajmone Marsan N, de Waha S, et al. 2023 ESC Guidelines for the management of endocarditis: Developed by the task force on the management of endocarditis of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM). Eur Heart J 2023;44:3948-4042.
2
Fowler VG, Durack DT, Selton-Suty C, et al. The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria. Clin Infect Dis 2023;77:518-526.
3
Cahill TJ, Prendergast BD. Infective endocarditis. Lancet 2016;387:882-893.
4
Şimşek-Yavuz S, Rüçhan Akar A, Aydoğdu S, et al. Diagnosis, treatment and prevention of infective endocarditis: Turkish consensus report. Klinik Dergisi 2019;32:2-116.
5
Wilson WR, Bower TC, Creager MA, et al. Vascular Graft Infections, Mycotic Aneurysms, and Endovascular Infections: A Scientific Statement From the American Heart Association. Circulation 2016;134:e412-e460.
6
Habib G, Erba PA, Iung B, et al. Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. Eur Heart J 2019;40:3222-3232.
7
Salsano A, Giacobbe DR, Del Puente F, et al. Culture-negative infective endocarditis (CNIE): impact on postoperative mortality. Open Med (Wars) 2020;15:571-579.
8
Zimmerli W, Sendi P. Pathogenesis of implant-associated infection: the role of the host. Semin Immunopathol 2011;33:295-306.
9
Erba PA, Sollini M, Lazzeri E, Mariani G. FDG-PET in cardiac infections. Semin Nucl Med 2013;43:377-395.
10
Mostaghim AS, Lo HYA, Khardori N. A retrospective epidemiologic study to define risk factors, microbiology, and clinical outcomes of infective endocarditis in a large tertiary-care teaching hospital. SAGE Open Med 2017;5:2050312117741772.
11
Toyoda N, Chikwe J, Itagaki S, Gelijns AC, Adams DH, Egorova NN. Trends in Infective Endocarditis in California and New York State, 1998-2013. JAMA 2017;317:1652-1660.
12
Di Salvo G, Habib G, Pergola V, et al. Echocardiography predicts embolic events in infective endocarditis. J Am Coll Cardiol 2001;37:1069-1076.
13
Habib G, Lancellotti P, Antunes MJ, et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 2015;36:3075-3128.
14
Juneau D, Golfam M, Hazra S, et al. Molecular Imaging for the diagnosis of infective endocarditis: A systematic literature review and meta-analysis. Int J Cardiol 2018;253:183-188.
15
Motwani M, Kidambi A, Herzog BA, Uddin A, Greenwood JP, Plein S. MR imaging of cardiac tumors and masses: a review of methods and clinical applications. Radiology 2013;268:26-43.
16
Saghir S, Ivey TD, Kereiakes DJ, Mazur W. Anterior mitral valve leaflet aneurysm due to infective endocarditis detected by cardiac magnetic resonance imaging. Rev Cardiovasc Med 2006;7:157-159.
17
Dursun M, Yilmaz S, Yilmaz E, et al. The utility of cardiac MRI in diagnosis of infective endocarditis: preliminary results. Diagn Interv Radiol 2015;21:28-33.
18
Osborne MT, Hulten EA, Murthy VL, et al. Patient preparation for cardiac fluorine-18 fluorodeoxyglucose positron emission tomography imaging of inflammation. J Nucl Cardiol 2017;24:86-99.
19
Scholtens AM, Verberne HJ, Budde RP, Lam MG. Additional Heparin Preadministration Improves Cardiac Glucose Metabolism Suppression over Low-Carbohydrate Diet Alone in (1)(8)F-FDG PET Imaging. J Nucl Med 2016;57:568-573.
20
Mathieu C, Mikail N, Benali K, et al. Characterization of (18)F-Fluorodeoxyglucose Uptake Pattern in Noninfected Prosthetic Heart Valves. Circ Cardiovasc Imaging 2017;10:e005585.
21
Roque A, Pizzi MN, Fernandez-Hidalgo N, et al. Morpho-metabolic post-surgical patterns of non-infected prosthetic heart valves by [18F]FDG PET/CTA: “normality” is a possible diagnosis. Eur Heart J Cardiovasc Imaging 2020;21:24-33.
22
Scholtens AM, Swart LE, Verberne HJ, Budde RPJ, Lam M. Dual-time-point FDG PET/CT imaging in prosthetic heart valve endocarditis. J Nucl Cardiol 2018;25:1960-1967.
23
Gomes A, Glaudemans A, Touw DJ, et al. Diagnostic value of imaging in infective endocarditis: a systematic review. Lancet Infect Dis 2017;17:e1-e14.
24
Calais J, Touati A, Grall N, et al. Diagnostic Impact of (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and White Blood Cell SPECT/Computed Tomography in Patients With Suspected Cardiac Implantable Electronic Device Chronic Infection. Circ Cardiovasc Imaging 2019;12:e007188.
25
Pijl JP, Glaudemans A, Slart R, Yakar D, Wouthuyzen-Bakker M, Kwee TC. FDG-PET/CT for Detecting an Infection Focus in Patients With Bloodstream Infection: Factors Affecting Diagnostic Yield. Clin Nucl Med 2019;44:99-106.
26
Rouzet F, Chequer R, Benali K, et al. Respective performance of 18F-FDG PET and radiolabeled leukocyte scintigraphy for the diagnosis of prosthetic valve endocarditis. J Nucl Med 2014;55:1980-1985.
27
Kamani CH, Allenbach G, Jreige M, et al. Diagnostic Performance of 18F-FDG PET/CT in Native Valve Endocarditis: Systematic Review and Bivariate Meta-Analysis. Diagnostics (Basel) 2020;10:754.
28
de Camargo RA, Sommer Bitencourt M, Meneghetti JC, et al. The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Left-sided Endocarditis: Native vs Prosthetic Valves Endocarditis. Clin Infect Dis 2019;70:583-594.
29
Duval X, Le Moing V, Tubiana S, et al. Impact of Systematic Whole-body 18F-Fluorodeoxyglucose PET/CT on the Management of Patients Suspected of Infective Endocarditis: The Prospective Multicenter TEPvENDO Study. Clin Infect Dis 2021;73:393-403.
30
Abou Jokh Casas E, Pubul Núñez V, Pombo Pasín MDC, et al. Advantages and limitations of 18-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography in the diagnosis of infective endocarditis. Rev Port Cardiol (Engl Ed) 2019;38:573-580.
31
Saby L, Laas O, Habib G, et al. Positron emission tomography/computed tomography for diagnosis of prosthetic valve endocarditis: increased valvular 18F-fluorodeoxyglucose uptake as a novel major criterion. J Am Coll Cardiol 2013;61:2374-2382.
32
San S, Ravis E, Tessonier L, et al. Prognostic Value of (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infective Endocarditis. J Am Coll Cardiol 2019;74:1031-1040.
33
Calais J, Touati A, Grall N, et al. Diagnostic Impact of (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and White Blood Cell SPECT/Computed Tomography in Patients With Suspected Cardiac Implantable Electronic Device Chronic Infection. Circ Cardiovasc Imaging 2019;12:e007188.
34
Diemberger I, Bonfiglioli R, Martignani C, et al. Contribution of PET imaging to mortality risk stratification in candidates to lead extraction for pacemaker or defibrillator infection: a prospective single center study. Eur J Nucl Med Mol Imaging 2019;46:194-205.
35
Pienta M, Shore S, Pagani FD, Likosky DS. Rates and types of infections in left ventricular assist device recipients: A scoping review. JTCVS Open 2021;8:405-411.
36
Ten Hove D, Treglia G, Slart R, et al. The value of (18)F-FDG PET/CT for the diagnosis of device-related infections in patients with a left ventricular assist device: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging 2021;48:241-253.
37
Memmott MJ, James J, Armstrong IS, Tout D, Ahmed F. The performance of quantitation methods in the evaluation of cardiac implantable electronic device (CIED) infection: A technical review. J Nucl Cardiol 2016;23:1457-1466.
38
Sarrazin JF, Philippon F, Tessier M, et al. Usefulness of fluorine-18 positron emission tomography/computed tomography for identification of cardiovascular implantable electronic device infections. J Am Coll Cardiol 2012;59:1616-1625.
39
Lucinian YA, Lamarche Y, Demers P, Martineau P, Harel F, Pelletier-Galarneau M. FDG-PET/CT for the Detection of Infection Following Aortic Root Replacement Surgery. JACC Cardiovasc Imaging 2020;13:1447-1449.
40
Garcia-Arribas D, Vilacosta I, Ortega Candil A, et al. Usefulness of positron emission tomography/computed tomography in patients with valve-tube graft infection. Heart 2018;104:1447-1454.
41
Rojoa D, Kontopodis N, Antoniou SA, Ioannou CV, Antoniou GA. 18F-FDG PET in the Diagnosis of Vascular Prosthetic Graft Infection: A Diagnostic Test Accuracy Meta-Analysis. Eur J Vasc Endovasc Surg 2019;57:292-301.
42
Guenther SP, Cyran CC, Rominger A, et al. The relevance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging in diagnosing prosthetic graft infections post cardiac and proximal thoracic aortic surgery. Interact Cardiovasc Thorac Surg 2015;21:450-458.
43
Pizzi MN, Dos-Subira L, Roque A, et al. (18)F-FDG-PET/CT angiography in the diagnosis of infective endocarditis and cardiac device infection in adult patients with congenital heart disease and prosthetic material. Int J Cardiol 2017;248:396-402.
44
Erba PA, Sollini M, Conti U, et al. Radiolabeled WBC scintigraphy in the diagnostic workup of patients with suspected device-related infections. JACC Cardiovasc Imaging 2013;6:1075-1086.
45
Holcman K, Malecka B, Rubis P, et al. The role of 99mTc-HMPAO-labelled white blood cell scintigraphy in the diagnosis of cardiac device-related infective endocarditis. Eur Heart J Cardiovasc Imaging 2020;21:1022-1030.
46
Holcman K, Szot W, Rubis P, et al. 99mTc-HMPAO-labeled leukocyte SPECT/CT and transthoracic echocardiography diagnostic value in infective endocarditis. Int J Cardiovasc Imaging 2019;35:749-758.
47
Erba PA, Conti U, Lazzeri E, et al. Added value of 99mTc-HMPAO-labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis. J Nucl Med 2012;53:1235-1243.
48
Erba PA, Lancellotti P, Vilacosta I, et al. Recommendations on nuclear and multimodality imaging in IE and CIED infections. Eur J Nucl Med Mol Imaging 2018;45:1795-1815.
49
Malecka BA, Zabek A, Debski M, et al. The usefulness of SPECT-CT with radioisotope-labeled leukocytes in diagnosing lead-dependent infective endocarditis. Adv Clin Exp Med 2019;28:113-119.
50
Pizzi MN, Roque A, Fernandez-Hidalgo N, et al. Improving the Diagnosis of Infective Endocarditis in Prosthetic Valves and Intracardiac Devices With 18F-Fluordeoxyglucose Positron Emission Tomography/Computed Tomography Angiography: Initial Results at an Infective Endocarditis Referral Center. Circulation 2015;132:1113-1126.