ABSTRACT
Ovarian cancer is one of the common gynecological malignancies in the world, and accurate diagnosis and staging are important because of its advanced stage diagnosis and low survival rates. While cytoreductive surgeries are performed in the early stages, debulking surgeries and platinum-based chemotherapy are the main treatment modalities in the advanced stages. Ovarian cancers spread most frequently by peritoneal spread which can form implants in the abdominal cavity, they also show hematological and lymphatic spread. In recent guidelines, F-18 fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) plays an important role in the treatment management of ovarian cancer with its accuracy in primary diagnosis, staging, prognosis, especially in the detection and restaging of implants. The limited use of F-18 FDG PET/CT has been shown in the literature in evaluation of treatment response, and it is noteworthy that it provides prognostic and predictive contribution with metabolic and anatomical parameters. There are also studies with different PET radiopharmaceuticals other than F-18 FDG in order to detect early tumor response, diagnose peritoneal carcinomatosis and evaluate treatment alternatives. In this review, the role of F-18 FDG PET/CT imaging in ovarian cancer clinical indications is presented.
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