ABSTRACT
Ga-68 DOTA-DPhe-Tyr3-octreotate (DOTATATE) positron emission tomography/computerised tomography (PET/CT) is the most widely used fuctional imaging method in diagnosis and follow up of neuroendocrine tumors (NET). Although therapies differ according to the differentiation grade and functional state of the tumor, mostly therapies targeting the somatostatin receptors overexpressed on the tumor cells are used. Peptide receptor radionuclide therapy (PRRT) is one of the most frequently used systemic therapies in NET’s and acting on this cascade. Radiological and functional methods in evaluation of therapy reponse in these tumors with slow metabolism, benign behaviour and slow growing rate are still a matter of debate. In this review, the place of Ga-68 DOTATATE PET/CT in evaluation of therapy response, especially PRRT in NET’s.