ABSTRACT
Together with the development of radiological methods like ultrasonography, computerized tomography and magnetic resonance imaging in liver and spleen imaging, scintigraphic imaging procedures are kept in the background. However, funtional imaging is still of choice in some indications, especially due to its high specificity. Innovations in gamma cameras in the last years, easier, fast and effective applicability of tomographic imaging, widespread availability of single photon emission comuted tomography/computed tomography hybrid imaging systems have led liver blood pool and selective spleen examinations to be performed with a higher detection power and accuracy. In this review, clinical applications of these two examinations and practice methods will be discussed.
Keywords:
Liver, spleen, scintigraphy, SPECT, SPECT/CT
References
1
Tait N, Richardson AJ, Muguti G, et al. Hepatic cavernous haemangioma: a 10 year review. Aust N Z J Surg 1992;62:521-524.
2
European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines on the management of benign liver tumours. J Hepatol 2016;65:386-398.
3
Royal HD, Brown ML, Drum DE, et al. Society of Nuclear Medicine Procedure Guideline for Hepatic and Splenic Imaging 2003:53-57.
4
Kim GE, Thung SN, Tsui WM, et al. Hepatic cavernous hemangioma: underrecognized associated histologic features. Liver Int 2006;26:334-338.
5
Middleton ML. Scintigraphic evaluation of hepatic mass lesions: emphasis on hemangioma detection. Semin Nucl Med 1996;26:4-15.
6
Yıldız A, Karayalçın B, Güngör F, ve ark. Karaciğer Hemanjiomunun Tanısında Kan Havuzu Spect Çalışmasının Yeri. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi 1993;7:22-26.
7
Tumeh SS, Benson C, Nagel JS, English RJ, Holman BL. Cavernous hemangioma of the liver: detection with single-photon emission computed tomography. Radiology 1987;164:353-356.
8
Intenzo C, Kim S, Madsen M, Park C. Planar and SPECT Tc-99m red blood cell imaging in hepatic cavernous hemangiomas and other hepatic lesions. Clin Nucl Med 1988;13:237-240.
9
Rabinowitz SA, McKusick KA, Strauss HW. 99mTc red blood cell scintigraphy in evaluating focal liver lesions. AJR Am J Roentgenol 1984;143:63-68.
10
Fundamentals Of Nuclear Pharmacy, 5th Edition, 2004, Saha GB, Characteristics of Specific Radiopharmaceuticals p:116.
11
Front D, Israel O, Groshar D, Weininger J. Technetium-99m-labeled red blood cell imaging. Semin Nucl Med 1984;14:226-250.
12
Rubin RA, Lichtenstein GR. Hepatic scintigraphy in the evaluation of solitary solid liver masses. J Nucl Med 1993;34:697-705.
13
Front D, Hardoff R, Israel O, Schneck SO. Perfusion vascularity mismatch in liver hemangiomas. Clin Nucl Med 1978;3:212-213.
14
Royal HD, Israel O, Parker JA, Kolodny GM. Scintigraphy of hepatic hemangiomas: the value of Tc-99m-labeled red blood cells: concise communication. J Nucl Med 1981;22:684-687.
15
Rossleigh MA, Singer I, Bautovich GJ, et al. Blood-pool studies of the liver. Diagnostic patterns exist in cavernous haemangioma. Med J Aust 1984;140:337-340.
16
Kudo M, Ikekubo K, Yamamoto K, et al. Distinction between hemangioma of the liver and hepatocellular carcinoma: value of labeled RBC-SPECT scanning. AJR Am J Roentgenol 1989;152:977-983.
17
Middleton ML, Milstein DM, Freeman LM. The importance of early dynamic images in diagnosing hepatic hemangiomas. Clin Nucl Med 1993;18:262.
18
Ali A, Berg R, Fordham EW. False-positive hepatic blood pool SPECT study for hepatic hemangioma. Clin Nucl Med 1994;19:687-688.
19
Swayne LC, Diehl WL, Brown TD, et al. False-positive hepatic blood pool scintigraphy in metastatic colon carcinoma. Clin Nucl Med 1991;16:630-632.
20
Farlow DC, Little JM, Gruenewald SM, Antico VF, O’Neill P. A case of metastatic malignancy masquerading as a hepatic hemangioma on labeled red blood cell scintigraphy. J Nucl Med 1993;34:1172-1174.
21
Groshar D, Ben-Haim S, Gips S, et al. Spectrum of scintigraphic appearance of liver hemangiomas. Clin Nucl Med 1992;17:294-299.
22
Gunes I, Yilmazlar T, Sarikaya I, Akbunar T, Irgil C. Scintigraphic detection of splenosis: Superiority of tomographic selective spleen scintigraphy. Clin Radiol 1994;49:115-117.
23
Ekmekçi Ş, Diz-Küçükkaya R, Türkmen C, et al. Selective Spleen Scintigraphy in the Evaluation of Accessory Spleen/Splenosis in Splenectomized/Nonsplenectomized Patients and the Contribution of SPECT Imaging. Mol Imaging Radionucl Ther 2015;24:1-7.
24
Phom H, Kumar A, Tripathi M, et al. Comparative evaluation of Tc-99m-heatdenatured RBC and Tc-99m-anti-D IgG opsonized RBC spleen planar and SPECT scintigraphy in the detection of accessory spleen in postsplenectomy patients with chronic idiopathic thrombocytopenic purpura. Clin Nucl Med 2004;29:403-409.
25
Alvarez R, Diehl KM, Avram A, Brown R, Piert M. Localization of splenosis using 99mTc-damaged red blood cell SPECT/CT and intraoperative gamma probe measurements. Eur J Nucl Med Mol Imaging 2007;34:969.
26
Horger M, Eschmann SM, Lengerke C, Claussen CD, Pfannenberg C, Bares R. Improved detection of splenosis in patients with haematological disorders:the role of combined transmission-emission tomography. Eur J Nucl Med Mol Imaging 2003;30:316-319.
27
Schillaci O, Flippi L, Danielli R, Simonetti G. Single-photon emission computed tomography/computed tomography in abdominal diseases. Semin Nucl Med 2007;37:48-61.
28
Barbaros U, Dinççağ A, Erbil Y, et al. Handheld gamma probe used to detect accessory spleens during initial laparoscopic splenectomies. Surg Endosc 2007;21:115-119.
