ABSTRACT
I-131 is the first most experienced theranostic radionuclide that has been used since the early 1940s for the treatment of hyperthyroidism, metastases or ablation of residual thyroid tissue in well-differentiated thyroid cancers. Although generally safe and very well tolerated, radioiodine therapy has some potential side effects classified as early and late complications. Early side effects include nausea, rarely vomiting, oral mucositis, sialadenitis, taste disturbance, gastrointestinal, gonadal and hematopoietic system dysfunction and radiation thyroiditis in the cases with large residual tissue. Late complications include secondary cancers, pulmonary fibrosis, and permanent bone marrow suppression. Early complications are generally due to the radioiodine activity and have transient nature, late complications are due to the cumulative radiation dose and are rare. The aim of this article is to review the potential side effects and complications of I-131 therapy and their clinical management.
Keywords:
Thyroid, radioiodine treatment, adverse effects
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