ABSTRACT
Infective endocarditis (IE) is described as infection of the endocardial surfaces of the heart and if available prosthesis materials. Despite all up-to-date developments in diagnosis and treatment, IE is a mortal and morbid disease. IE causes numerous non-specific symptoms and findings in patients. Currently, various difficulties are observed in diagnosis and differential diagnosis of IE. Duke criteria is used to support the diagnosis. Also, echocardiography, computed tomography (CT), positron emission tomography (PET)/CT, magnetic resonance, labeled leukocyte scintigraphy, blood culture, and polymerase chain reaction investigations are used. However, histopathological diagnosis is the gold standard. In this review, we discuss nuclear medicine methods (PET/CT and labeled leukocyte scintigraphy) that found place in current international practice guidelines in recent years for diagnosis of IE.