ABSTRACT
Nowadays, beta (β-) and alpha emitters have been used for radionuclide therapy in all over the world. Most commonly used I-131 and Lu-177 are considered efficient for therapy as they emit β- particles and also have diagnostic contribution due to its gamma emission, however, relative risk related to gamma radiation exposure to the patients and environment should be considered. Therefore, all the workers within the radiation field, care givers, and general public are invited to commit the rules and regulations of radiation protection. In more details, following I-131 therapy for thyroid cancer, radiation protection instructions must be applied up to one week and for hyperthyroidism-up to three weeks. Following Lu-177 therapy, isolation for 6 hours is acceptable for adequate radiation safety. Regarding Y-90 therapy which poses no exposure risk to the environment and public, patient admission to hospital is performed only to provide enough monitoring and observation.