ABSTRACT
Among all existing alpha emitting radionuclides, Actinium-225 (Ac-225), Astatine-211 (At-211), Bismuth-212 (Bi-212), Bismuth-213 (Bi-213), Lead-212 (Pb-212), Radium-223 (Ra-223), Terbium-149 (Tb-149) and Thorium-227 (Th-227) are notable radionuclides with potential therapeutic application in targeted alpha therapy. This review aims to provide overview of the key properties of three selected radionuclides, Pb-212, Th-227, At-211, Tb-149. An overview from their availability to the resulting clinical studies, by way of chemical design and preclinical studies is discussed.
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